Role of the interaction between large T antigen and Rb family members in the oncogenicity of JC virus

被引:44
作者
Caracciolo, V.
Reiss, K.
Khalili, K.
De Falco, G.
Giordano, A.
机构
[1] Temple Univ, Sbarro Inst Canc Res & Mol Med, Dept Biol, Philadelphia, PA 19122 USA
[2] Temple Univ, Ctr Neurovirol, Dept Neurosci, Philadelphia, PA 19122 USA
[3] Univ Siena, Dept Human Pathol & Oncol, I-53100 Siena, Italy
关键词
JCV T antigen; retinoblastoma family proteins; cell cycle;
D O I
10.1038/sj.onc.1209681
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Human polyomaviruses (JC virus, BK virus and simian virus 40) are causative agents of some human diseases and, interestingly, are involved in processes of cell transformation and oncogenesis. These viruses need the cell cycle machinery of the host cell to complete their replication; so they evolved mechanisms that can interfere with the growth control of infected cells and force them into DNA replication. The retinoblastoma family of proteins (pRb), which includes pRb/p105, p107 and pRb2/p130, acts as one of the most important regulators of the G1/S transition of the cell cycle. Rb proteins represent an important target for viral oncoproteins. Early viral T antigens can bind all members of the pRb family, promoting the activation of the E2F family of transcription factors, thus inducing the expression of genes required for the entry to the S phase. The interaction between early viral antigens and cell cycle regulators represents an important mechanism through which viruses deregulate cell cycle and lead to cell transformation. In this review, we will discuss the effects of the interaction between large T antigen and Rb proteins in JC virus-mediated oncogenesis.
引用
收藏
页码:5294 / 5301
页数:8
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