The serotonin transporter gene and peer-rated neuroticism

被引：117

作者：

Ball, D

Hill, L

Freeman, B

Eley, TC

Strelau, J

Riemann, R

Spinath, FM

Angleitner, A

Plomin, R

机构：

[1] INST PSYCHIAT,SOCIAL GENET & DEV PSYCHIAT RES CTR,LONDON SE5 8AF,ENGLAND

[2] UNIV WARSAW,DEPT PSYCHOL,PL-00325 WARSAW,POLAND

[3] UNIV BIELEFELD,FAK PSYCHOL & SPROTWISSENSCH,D-33501 BIELEFELD,GERMANY

来源：

NEUROREPORT | 1997年 / 8卷 / 05期

关键词：

depression; neuroticism; polymorphism; risk factors; serotonin transporter;

D O I：

10.1097/00001756-199703240-00048

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

POLYMORPHISMS in the serotonin transporter gene (5HTT) have been reported to be associated with neuroticism (emotionality) and with depression. A recent report of an association between 5HTT and neuroticism involved unselected samples and self-report questionnaires.(1) We attempted to extend these findings using a selected extremes design and peer ratings. From a sample of 2085 individuals, each assessed on neuroticism by two independent peers, we selected 52 individuals from the top 5% and 54 individuals from the bottom 5%. No association was found for either a functional 44 bp insertion/deletion polymorphism in 5HTT regulatory sequence (5HTTLPR) or for a non-functional variable number tandem repeat 5HTT polymorphism.

引用

页码：1301 / 1304

页数：4

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