Induction of apoptosis in a human breast cancer cell overexpressing ErbB-2 receptor by α-tocopheryloxybutyric acid

被引：24

作者：

Akazawa, A

Nishikawa, K

Suzuki, K

Asano, R

Kumadaki, I

Satoh, H

Hagiwara, K

Shin, SJ

Yano, T

机构：

[1] Natl Inst Hlth & Nutr, Dept Food Sci Res Hlth, Shinjuku Ku, Tokyo 1628636, Japan

[2] Nihon Univ, Coll Bioresource Sci, Dept Vet Pharmacol, Kanagawa 2528510, Japan

[3] Setsunan Univ, Fac Pharmaceut Sci, Osaka 5730101, Japan

来源：

JAPANESE JOURNAL OF PHARMACOLOGY | 2002年 / 89卷 / 04期

关键词：

alpha-tocopheryloxybutyric acid; apoptosis; breast cancer cell;

D O I：

10.1254/jjp.89.417

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The overexpression of ErbB-2 receptor relates to malignant transformation of breast cancer. The present study was carried out to establish the usefulness of a-tocopheryloxybutyric acid (TE) as a chemotherapeutic agent for human breast cancer. TE caused induction of apoptosis in MDA-MB-453 cells overexpressing the ErbB-2 receptor. TE reduced levels of activated ErbB-2 receptor and Akt. In contrast, TE induced the activation of p38, and SB203580, a specific inhibitor for p38, attenuated the TE-induced apoptosis. These data indicate that simultaneous occurrences of Akt inhibition and p38 activation by TE result in the cell death.

引用

页码：417 / 421

页数：5

共 17 条

[1] The activation of p38 and apoptosis by the inhibition of ERK is antagonized by the phosphoinositide S-kinase/Akt pathway [J].