Effects of aluminum exposure on behavioral parameters in the rat

被引：40

作者：

StruysPonsar, C

Kerkhofs, A

Gauthier, A

Soffie, M

DeAguilar, PV

机构：

[1] UNIV CATHOLIQUE LOUVAIN, LAB BIOL ANIM, UNITE BANI, B-1348 LOUVAIN, BELGIUM

[2] UNIV CATHOLIQUE LOUVAIN, UNITE PSYCHOBIOL, B-1348 LOUVAIN, BELGIUM

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1997年 / 56卷 / 04期

关键词：

aluminum gluconate; rat; brain aluminum; radial maze; spatial memory; latency;

D O I：

10.1016/S0091-3057(96)00515-1

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Adult rats were treated by intraperitoneal injection of aluminum gluconate for 3 months. Rats were submitted to the radial maze test to determine the influence of chronic aluminum intoxication on cognitive and noncognitive behavioral processes. Both learning abilities (working memory and reference memory) and rapidity (time spent to respond and to master a trial) were analyzed. Aluminum concentration was evaluated in the brain, serum, and liver to assess aluminum body burden. While hippocampus and neocortex showed a significant increase in aluminum concentration, aluminum treatment did never affect the animal's performance during cue learning or when the insert cues were removed. The only behavioral difference observed was a decrease in rapidity: both the total time to finish a trial and the latency to make the first choice were lengthened in aluminum-intoxicated rats. (C) 1997 Elsevier Science Inc.

引用

页码：643 / 648

页数：6

共 31 条

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