Lanthanide Luminescent Bioprobes (LLBs)

被引：160

作者：

Buenzli, Jean-Claude G. ^{[1
]}

机构：

[1] Swiss Fed Inst Technol Lausanne EPFL, Lab Lanthanide Supramol Chem, CH-1015 Lausanne, Switzerland

来源：

CHEMISTRY LETTERS | 2009年 / 38卷 / 02期

基金：

瑞士国家科学基金会;

关键词：

NEAR-INFRARED LUMINESCENCE; RESONANCE ENERGY-TRANSFER; NANOPARTICLE LABELS; IMAGING PROBES; LIVING CELLS; COMPLEXES; EUROPIUM; CHELATE; DESIGN; ANION;

D O I：

10.1246/cl.2009.104

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Lanthanide luminescent bioprobes (LLBs) are amongst the most sensitive luminescent probes because their excited states are long-lived, which allows time-resolved detection (TRD) of their luminescence, boosting the signal-to-noise ratio and the sensitivity in addition they are fairly insensitive to photobleaching since lanthanide ions are good quenchers of triplet states. Applications of LLBs to immunoassays, DNA analysis, ligand binding assays, analyte sensing, and cellular imaging are reviewed. Future developments in immunohistochemistry, targeting of specific organelles, lab-on-a-chip technology, and instrumental design are evoked.

引用

页码：104 / 109

页数：6

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