The high pressure reaction of cyclopropanes with indoles catalyzed by ytterbium triflate

被引：91

作者：

Harrington, P ^{[1
]}

Kerr, MA ^{[1
]}

机构：

[1] ACADIA UNIV,DEPT CHEM,WOLFVILLE,NS B0P 1X0,CANADA

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 34期

关键词：

D O I：

10.1016/S0040-4039(97)01351-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A variety of 1,1-cyclopropane dicarboxylic acid esters were reacted with a selection of indoles under hyperbarric conditions. In the presence of Yb(OTf)(3) . 3H(2)O, smooth ring opening resulted in the formation of 4-indolyl dicarboxylic acid esters. Hydrolysis and decarboxylation resulted in the formation of the mono-acids. Nucleophilic attack occurred specifically at the more hindered position of the substituted cyclopropanes. (C) 1997 Elsevier Science Ltd.

引用

页码：5949 / 5952

页数：4

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