ENaC at the Cutting Edge: Regulation of Epithelial Sodium Channels by Proteases

被引：246

作者：

Kleyman, Thomas R. ^{[1
,2
]}

Carattino, Marcelo D. ^{[1
]}

Hughey, Rebecca P. ^{[1
,2
]}

机构：

[1] Univ Pittsburgh, Dept Med, Renal Electrolyte Div, Pittsburgh, PA 15261 USA

[2] Univ Pittsburgh, Dept Cell Biol & Physiol, Pittsburgh, PA 15261 USA

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2009年 / 284卷 / 31期

基金：

美国国家卫生研究院;

关键词：

SURFACE LIQUID VOLUME; GAMMA-SUBUNIT; NA+ CHANNEL; CYSTIC-FIBROSIS; XENOPUS-OOCYTES; ALPHA-SUBUNIT; RAT-KIDNEY; PROTEOLYTIC ACTIVATION; ELASTASE ACTIVATION; SERINE PROTEASES;

D O I：

10.1074/jbc.R800083200

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Epithelial Na+ channels facilitate the transport of Na+ across high resistance epithelia. Proteolytic cleavage has an important role in regulating the activity of these channels by increasing their open probability. Specific proteases have been shown to activate epithelial Na+ channels by cleaving channel subunits at defined sites within their extracellular domains. This minireview addresses the mechanisms by which proteases activate this channel and the question of why proteolysis has evolved as a mechanism of channel activation.

引用

页码：20447 / 20451

页数：5

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