Immunologic NO synthase: Elevation in severe AIDS dementia and induction by HIV-1 gp41

被引：362

作者：

Adamson, DC

Wildemann, B

Sasaki, M

Glass, JD

McArthur, JC

Christov, VI

Dawson, TM

Dawson, VL

机构：

[1] JOHNS HOPKINS UNIV,SCH MED,DEPT NEUROL,BALTIMORE,MD 21287

[2] JOHNS HOPKINS UNIV,SCH MED,DEPT NEUROSCI,BALTIMORE,MD 21287

[3] JOHNS HOPKINS UNIV,SCH MED,DEPT PHYSIOL,BALTIMORE,MD 21287

[4] JOHNS HOPKINS UNIV,SCH MED,DEPT PATHOL,BALTIMORE,MD 21287

[5] JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,DEPT EPIDEMIOL,BALTIMORE,MD 21287

来源：

SCIENCE | 1996年 / 274卷 / 5294期

关键词：

D O I：

10.1126/science.274.5294.1917

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Indirect mechanisms are implicated in the pathogenesis of the dementia associated with human immunodeficiency virus-typo 1 (HIV-1) infection. Proinflammatory molecules such as tumor necrosis factor alpha and eicosanoids are elevated in the central nervous system of patients with HIV-1-related dementia. Nitric oxide (NO) is a potential mediator of neuronal injury, because cytokines may activate the immunologic (type II) isoform of No synthase (iNOS). The levels of iNOS in severe HIV-1-associated dementia coincided with increased expression of the HIV-1 coat protein gp41. Furthermore, gp41 induced iNOS in primary cultures of mixed rat neuronal and glial cells and killed neurons through a NO-dependent mechanism. Thus, gp41-induced NO formation may contribute to the severe cognitive dysfunction associated with HIV-1 infection.

引用

页码：1917 / 1921

页数：5

共 69 条

[1] Neurovirulent Simian immunodeficiency virus infection induces neuronal, endothelial, and glial apoptosis [J].