Follicular dendritic cells: origin, phenotype, and function in health and disease

被引：128

作者：

Aguzzi, Adriano ^{[1
]}

Kranich, Jan ^{[2
]}

Krautler, Nike Julia ^{[3
]}

机构：

[1] Univ Zurich, Inst Neuropathol, Zurich, Switzerland

[2] Univ Munich, Inst Immunol, D-80539 Munich, Germany

[3] Garvan Inst Med Res, Sydney, NSW, Australia

来源：

TRENDS IN IMMUNOLOGY | 2014年 / 35卷 / 03期

关键词：

follicular dendritic cells; fibroblastic reticular cells; secondary lymphoid organs; tertiary lymphoid tissues; germinal center; lymphoid organogenesis; CENTER B-CELLS; FIBROBLASTIC RETICULAR CELLS; GERMINAL CENTER; APOPTOTIC CELLS; LYMPH-NODE; T-CELLS; AUTOANTIBODY PRODUCTION; COMPLEMENT PROTEIN; PRION REPLICATION; IMPAIRED UPTAKE;

D O I：

10.1016/j.it.2013.11.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Follicular dendritic cells (FDCs) were originally identified by their specific morphology and by their ability to trap immune-complexed antigen in B cell follicles. By virtue of the latter as well as the provision of chemokines, adhesion molecules, and trophic factors, FDCs participate in the shaping of B cell responses. Importantly, FDCs also supply tingible body macrophages (TBMs) with the eat-me-signaling molecule milk fat globule-EGF factor 8 (Mfge8), thereby enabling the disposal of apoptotic B cells. Recent studies have provided fundamental insights into the multiple functions of FDCs in both physiological and pathophysiological contexts and into their origin. Here we review these findings, and discuss current concepts related to FDC histogenesis both in lymphoid organs and in inflammatory lymphoneogenesis.

引用

页码：105 / 113

页数：9

共 94 条

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