SIRT1 and other sirtuins in metabolism

被引：933

作者：

Chang, Hung-Chun ^{[1
,2
]}

Guarente, Leonard ^{[3
,4
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Shanghai 200025, Peoples R China

[2] Shanghai Jiao Tong Univ, Sch Med, Shanghai 200025, Peoples R China

[3] MIT, Dept Biol, Glenn Lab Sci Aging, Cambridge, MA 02139 USA

[4] MIT, David H Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2014年 / 25卷 / 03期

关键词：

sirtuins; SIRT1; calorie restriction; aging; metabolism; CR mimetics; NAD(+); FATTY-ACID OXIDATION; ACTIVATED PROTEIN-KINASE; HISTONE DEACETYLASE SIRT6; SMALL-MOLECULE ACTIVATORS; REGULATES LIFE-SPAN; CALORIE RESTRICTION; SACCHAROMYCES-CEREVISIAE; ADIPOSE-TISSUE; TUMOR-SUPPRESSOR; MITOCHONDRIAL-FUNCTION;

D O I：

10.1016/j.tem.2013.12.001

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Sirtuins such as SIRT1 are conserved protein NAD(+)-dependent deacylases and thus their function is intrinsically linked to cellular metabolism. Over the past two decades, accumulating evidence has indicated that sirtuins are not only important energy status sensors but also protect cells against metabolic stresses. Sirtuins regulate the aging process and are themselves regulated by diet and environmental stress. The versatile functions of sirtuins including, more specifically, SIRT1 are supported by their diverse cellular location allowing cells to sense changes in energy levels in the nucleus, cytoplasm, and mitochondrion. SIRT1 plays a critical role in metabolic health by deacetylating many target proteins in numerous tissues, including liver, muscle, adipose tissue, heart, and endothelium. This sirtuin also exerts important systemic effects via the hypothalamus. This review will cover these topics and suggest that strategies to maintain sirtuin activity may be on the horizon to forestall diseases of aging.

引用

页码：138 / 145

页数：8

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