Regional deposition of inhaled hygroscopic aerosols: In vivo SPECT compared with mathematical modeling

被引:44
作者
Finlay, WH
Stapleton, KW
Chan, HK
Zuberbuhler, P
Gonda, I
机构
[1] UNIV ALBERTA HOSP, CIST FIBROSIS & PEDIAT CLIN, EDMONTON, AB T6G 2G3, CANADA
[2] UNIV SYDNEY, DEPT PHARM, SYDNEY, NSW 2006, AUSTRALIA
[3] ARADIGM CORP, HAYWARD, CA 94545 USA
关键词
gamma scintigraphy; numerical; lung; computer; radiolabel; single-photon-emission computerized tomography;
D O I
10.1152/jappl.1996.81.1.374
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
The regional deposition patterns of inhaled hygroscopic aerosols obtained in vivo in the studies of Phipps et al. (P. R Phipps, I. Gonda, D. L. Bailey, P. Borham, G. Bautovich, and S. D. Anderson. Am. Rev. Respir. Dis. 139: 1516, 1989; and P. R. Phipps, I. Gonda, S. D. Anderson, D. L. Bailey, and G. Bautovich. Eur. Respir. J. 7: 1474-1482, 1994) and Chan et al. (H.-K. Chan, P. R. Phipps, I. Gonda, P. Cook, R. Fulton, I. Young, and G. Bautovich. Eur. Respir. J. 7: 1483-1489, 1994) by using single-photon-emission computerized tomography (SPECT) are compared with the regional deposition predicted by the hygroscopic lung deposition model of Finlay and Stapleton (W. H. Finlay and K, W. Stapleton. J. Aerosol Sci. 26: 655-670, 1995). Three pairs of saline aerosols are considered: isotonic with small [2.6-mu m mass median aerodynamic diameter (MMAD), geometric standard deviation (GSD) 1.4] vs. large (5.5-mu m MMAD, GSD 1.7) droplets; hypotonic (0.3% NaCl) vs. hypertonic (4.5% NaCl) with 3.7- to 3.8 mu m MMAD (GSD 1.4), and hypotonic vs. hypertonic (3.7- to 3.8-mu m MMAD, GSD 1.5-1.8) with reduced number of droplets per cubic centimeter For each of the three pairs of aerosols, no significant difference (P > 0.05) was found between thrill vivo and computational results for either the mean value or the variance of the difference in peripheral to central deposition. Thus it appears that theoretical calculations can be used to predict the pattern of lung deposition of hygroscopic aerosols in populations of normal subjects.
引用
收藏
页码:374 / 383
页数:10
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