Circulating TNF Receptors 1 and 2 Predict Mortality in Patients with End-stage Renal Disease Undergoing Dialysis

被引：51

作者：

Gohda, Tomohito ^{[1
]}

Maruyama, Shuntaro ^{[1
]}

Kamei, Nozomu ^{[2
,3
]}

Yamaguchi, Saori ^{[1
]}

Shibata, Terumi ^{[1
]}

Murakoshi, Maki ^{[1
]}

Horikoshi, Satoshi ^{[1
]}

Tomino, Yasuhiko ^{[1
]}

Ohsawa, Isao ^{[4
]}

Gotoh, Hiromichi ^{[4
]}

Nojiri, Shuko ^{[5
]}

Suzuki, Yusuke ^{[1
]}

机构：

[1] Juntendo Univ, Fac Med, Dept Internal Med, Div Nephrol,Bunkyo Ku, Tokyo 1138421, Japan

[2] Hiroshima Red Cross Hosp, Div Endocrinol & Metab, Dept Internal Med, Naka Ku, Hiroshima 7308619, Japan

[3] Atom Bomb Survivors Hosp, Naka Ku, Hiroshima 7308619, Japan

[4] Saiyu Soka Hosp, Dept Internal Med, Soka, Saitama 3400041, Japan

[5] Juntendo Univ, Clin Res Support Ctr JCRSC, Bukyo Ku, Tokyo 1138421, Japan

来源：

SCIENTIFIC REPORTS | 2017年 / 7卷

关键词：

NECROSIS-FACTOR RECEPTORS; C-REACTIVE PROTEIN; FACTOR-ALPHA; HEMODIALYSIS-PATIENTS; DIABETES-MELLITUS; BLOOD-PRESSURE; ASSOCIATION; TYPE-2; RISK; INFLAMMATION;

D O I：

10.1038/srep43520

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

Relatively high circulating levels of soluble tumor necrosis factor (TNF) receptors (TNFRs: TNFR1, TNFR2) have been associated with not only progression to end-stage renal disease but also mortality in patients with diabetes. It remains unknown whether elevated TNFR levels in haemodialysis patients are associated with mortality. We studied 319 patients receiving maintenance haemodialysis who were followed for a median of 53 months. Circulating markers of TNF pathway (TNF alpha and TNFRs) were measured with immunoassay. Strong positive correlations between TNFR1 and TNFR2 were observed (r = 0.81, P < 0.0001). During follow-up, 88 (27.6%) patients died of any cause (40 [45.5%] died of cardiovascular disease). In the Cox multivariate model, either TNFR but not TNF alpha remained a significant independent predictor of all-cause mortality (TNFR1: hazard ratio [HR] 2.34, 95% confidence interval [CI], 1.50-3.64; TNFR2: HR 2.13, 95% CI 1.38-3.29) after adjustment for age, prior cardiovascular disease, predialysis systolic blood pressure, and large systolic blood pressure decline during dialysis session. For cardiovascular mortality, significance was only observed in TNFR1 (TNFR1: HR 2.15, 95% CI 1.13-4.10). Elevated TNFRs levels were associated with the risk of cardiovascular and/ or all-cause mortality independent of all relevant covariates in patients undergoing haemodialysis.

引用

页数：10

共 43 条

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