Normal function of the transcription factor NFAT1 in wasted mice. Chromosome localization of NFAT1 gene

被引：4

作者：

Luo, C

Copeland, NG

Jenkins, NA

Edelhoff, S

Disteche, C

Hogan, PG

Rao, A

机构：

[1] HARVARD UNIV,SCH MED,DANA FARBER CANC INST,DIV CELL & MOL BIOL,BOSTON,MA 02115

[2] HARVARD UNIV,SCH MED,DEPT PATHOL,BOSTON,MA 02115

[3] HARVARD UNIV,SCH MED,DEPT NEUROBIOL,BOSTON,MA 02115

[4] NCI,FREDERICK CANC RES & DEV CTR,ABL BASIC RES PROGRAM,MAMMALIAN GENET LAB,FREDERICK,MD 21701

[5] UNIV WASHINGTON,SCH MED,DEPT PATHOL,SEATTLE,WA 98195

来源：

GENE | 1996年 / 180卷 / 1-2期

关键词：

DNA-binding protein; genetic diseases; RNA splicing; cytokine gene expression; T cell activation; transcription regulation;

D O I：

10.1016/S0378-1119(96)00396-4

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

NFAT1 (NFATp), a cytosolic component of the nuclear factor of activated T cells (NFAT), is encoded by a single gene which was mapped to mouse chromosome 2 in the vicinity of the wasted (wst) locus. Although wasted mice display a severe immune disorder, they express normal levels of NFAT1 protein. The NFAT1 protein in wasted mice is properly regulated and possesses comparable DNA binding activity as that in their littermate controls. Therefore, the wasted phenotype is not due to a defect in the expression or early regulation of the NFAT1 protein.

引用

页码：29 / 36

页数：8

共 31 条

[1] INTERACTION OF ENDOTHELIN-3 WITH ENDOTHELIN-B RECEPTOR IS ESSENTIAL FOR DEVELOPMENT OF EPIDERMAL MELANOCYTES AND ENTERIC NEURONS [J].