Immunomodulatory effect of antidepressants

被引：28

作者：

Szelényi, J ^{[1
]}

Selmeczy, Z ^{[1
]}

机构：

[1] Hungarian Acad Sci, Inst Expt Med, Dept Pharmacol, H-1450 Budapest, Hungary

来源：

CURRENT OPINION IN PHARMACOLOGY | 2002年 / 2卷 / 04期

基金：

匈牙利科学研究基金会;

关键词：

D O I：

10.1016/S1471-4892(02)00173-X

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Basic and clinical studies have provided evidence that the biophase level of monoamines, determined by the balance of their release and uptake, is involved in the pathophysiology and treatment of depression, whereas other arguments cite the role of inflammatory mediators in the etiology of psychiatric disorders. A bidirectional interaction between the monoamine system and the inflammatory system might explain the concurrent therapeutical efficacy and immunomodulatory features of antidepressants.

引用

页码：428 / 432

页数：5

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