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Vascular control in humans: focus on the coronary microcirculation

被引：65
作者：
Liu, Yanping [2 ]
Gutterman, David D. [1 ,3 ]
机构：
[1] Med Coll Wisconsin, Milwaukee, WI 53226 USA
[2] NIH, Natl Ctr Res Resources, Bethesda, MD 20892 USA
[3] Med Coll Wisconsin, Dept Med & Cardiovasc Ctr, Vet Adm Med Ctr, Milwaukee, WI 53226 USA
来源：
BASIC RESEARCH IN CARDIOLOGY | 2009年 / 104卷 / 03期
关键词：
coronary circulation; myogenic response; flow-mediated dilation; EDHF; reactive oxygen species; diabetes; K+ channels; SENSITIVE POTASSIUM CHANNELS; EPOXYGENASE-DERIVED EICOSANOIDS; CA2+-ACTIVATED K+ CHANNELS; MESENTERIC SMALL ARTERIES; FLOW-INDUCED DILATION; SMOOTH-MUSCLE-CELLS; ENDOTHELIUM-DEPENDENT HYPERPOLARIZATION; LEFT-VENTRICULAR HYPERTROPHY; INTERNAL MAMMARY ARTERY; CAMP-MEDIATED DILATION;
D O I：
10.1007/s00395-009-0775-y
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Myocardial perfusion is regulated by a variety of factors that influence arteriolar vasomotor tone. An understanding of the physiological and pathophysiological factors that modulate coronary blood flow provides the basis for the judicious use of medications for the treatment of patients with coronary artery disease. Vasomotor properties of the coronary circulation vary among species. This review highlights the results of recent studies that examine the mechanisms by which the human coronary microcirculation is regulated in normal and disease states, focusing on diabetes. Multiple pathways responsible for myogenic constriction and flow-mediated dilation in human coronary arterioles are addressed. The important role of endothelium-derived hyperpolarizing factors, their interactions in mediating dilation, as well as speculation regarding the clinical significance are emphasized. Unique properties of coronary arterioles in human vs. other species are discussed.
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收藏
页码：211 / 227
页数：17
相关论文
共 156 条
[1]   Ionic mechanisms mediating the myogenic response in newborn porcine cerebral arteries [J].
Ahmed, A ;
Waters, CM ;
Leffler, CW ;
Jaggar, JH .
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2004, 287 (05) :H2061-H2069
[2]   Endothelial responses to mechanical stress: Where is the mechanosensor? [J].
Ali, MH ;
Schumacker, PT .
CRITICAL CARE MEDICINE, 2002, 30 (05) :S198-S206
[3]  
ALUER T, 2008, BASIC RES CARDIOL, V103, P291
[4]   Mitochondrial metabolism of reactive oxygen species [J].
Andreyev, AI ;
Kushnareva, YE ;
Starkov, AA .
BIOCHEMISTRY-MOSCOW, 2005, 70 (02) :200-214
[5]   Endothelium-derived hyperpolarizing factor in human internal mammary artery is 11,12-epoxyeicosatrienoic acid and causes relaxation by activating smooth muscle BKCa channels [J].
Archer, SL ;
Gragasin, FS ;
Wu, XC ;
Wang, SH ;
McMurtry, S ;
Kim, DH ;
Platonov, M ;
Koshal, A ;
Hashimoto, K ;
Campbell, WB ;
Falck, JR ;
Michelakis, ED .
CIRCULATION, 2003, 107 (05) :769-776
[6]   Alterations in the endothelial G-protein coupled receptor pathway in epicardial arteries and subendocardial arterioles in compensated left ventricular hypertrophy [J].
Aubin, Marie-Claude ;
Gendron, Marie-Eve ;
Lebel, Vickie ;
Thorin, Eric ;
Tardif, Jean-Claude ;
Carrier, Michel ;
Perrault, Louis P. .
BASIC RESEARCH IN CARDIOLOGY, 2007, 102 (02) :144-153
[7]   Signal transduction in spontaneous myogenic tone in isolated arterioles from rat skeletal muscle [J].
Bakker, ENTP ;
Kerkhof, CJM ;
Sipkema, P .
CARDIOVASCULAR RESEARCH, 1999, 41 (01) :229-236
[8]   Mediators of bradykinin-induced vasorelaxation in human coronary microarteries [J].
Batenburg, WW ;
Garrelds, IM ;
van Kats, JP ;
Saxena, PR ;
Danser, AHJ .
HYPERTENSION, 2004, 43 (02) :488-492
[9]   Nitric oxide attenuates the release of endothelium-derived hyperpolarizing factor [J].
Bauersachs, J ;
Popp, R ;
Hecker, M ;
Sauer, E ;
Fleming, I ;
Busse, R .
CIRCULATION, 1996, 94 (12) :3341-3347
[10]   Augmented α-adrenergic constriction of atherosclerotic human coronary arteries [J].
Baumgart, D ;
Haude, M ;
Görge, G ;
Liu, FQ ;
Ge, JB ;
Grosse-Eggebrecht, C ;
Erbel, R ;
Heusch, G .
CIRCULATION, 1999, 99 (16) :2090-2097
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