Inkjet printing for pharmaceutical applications

被引：147

作者：

Boehm, Ryan D. ^{[1
,2
]}

Miller, Philip R. ^{[1
,2
]}

Daniels, Justin ^{[3
]}

Stafslien, Shane ^{[3
]}

Narayan, Roger J. ^{[1
,2
]}

机构：

[1] Univ N Carolina, Joint Dept Biomed Engn, Raleigh, NC 27695 USA

[2] N Carolina State Univ, Raleigh, NC 27695 USA

[3] N Dakota State Univ, Ctr Nanoscale Sci & Engn, Fargo, ND 58102 USA

来源：

MATERIALS TODAY | 2014年 / 17卷 / 05期

基金：

美国国家科学基金会;

关键词：

ORAL DOSAGE FORMS; AMPHOTERICIN-B; FABRICATION; MICROPARTICLES; TECHNOLOGY; DRUGS; ARRAY; SKIN;

D O I：

10.1016/j.mattod.2014.04.027

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Miconazole is an imidazole used for treatment of fungal infections that exhibits poor solubility in polar solvents (e.g., aqueous solutions). Microneedles, small-scale lancet-shaped devices that are commonly used for delivery of pharmacologic agents and vaccines, were made out of an acid anhydride copolymer using visible light dynamic mask micro-stereolithography/micromolding and loaded with miconazole using a piezoelectric inkjet printer. The miconazole-coated microneedles showed biodegradation and antifungal activity against the organism Candida albicans (ATCC 90028) on Sabouraud dextrose agar using an in vitro agar plating method. The results of this study demonstrate that piezoelectric inkjet printing may be used load microneedles and other drug delivery devices with pharmacologic agents. Miconazole-loaded microneedles prepared by the visible light dynamic mask micro-stereolithography-micromolding-piezoelectric inkjet printing approach have potential use in transdermal treatment of cutaneous fungal infections.

引用

页码：247 / 252

页数：6

共 47 条

[1]

Antohe B. V., 2008, P 2008 INT MAN SCI E

[2] Modification of microneedles using inkjet printing [J].

Boehm, R. D. ;

Miller, P. R. ;

Hayes, S. L. ;

Monteiro-Riviere, N. A. ;

Narayan, R. J. .

AIP ADVANCES, 2011, 1 (02)

[3] Inkjet Printing of Amphotericin B onto Biodegradable Microneedles Using Piezoelectric Inkjet Printing [J].

Boehm, Ryan D. ;

Miller, Philip R. ;

Schell, Wiley A. ;

Perfect, John R. ;

Narayan, Roger J. .

JOM, 2013, 65 (04) :525-533

[4] Indirect rapid prototyping of antibacterial acid anhydride copolymer microneedles [J].

Boehm, Ryan D. ;

Miller, Philip R. ;

Singh, Ritika ;

Shah, Akash ;

Stafslien, Shane ;

Daniels, Justin ;

Narayan, Roger J. .

BIOFABRICATION, 2012, 4 (01)

[5] Inhibition of neutrophil elastase prevents cathelicidin activation and impairs clearance of bacteria from wounds [J].

Cole, AM ;

Shi, JS ;

Ceccarelli, A ;

Kim, YH ;

Park, A ;

Ganz, T .

BLOOD, 2001, 97 (01) :297-304

[6] Applications of ink-jet printing technology to BioMEMS and microfluidic systems [J].

Cooley, P ;

Wallace, D ;

Antohe, B .

MICROFLUIDICS AND BIOMEMS, 2001, 4560 :177-188

[7] Inkjet printing of proteins [J].

Delaney, Joseph T., Jr. ;

Smith, Patrick J. ;

Schubert, Ulrich S. .

SOFT MATTER, 2009, 5 (24) :4866-4877

[8] Inkjet Printing of Functional and Structural Materials: Fluid Property Requirements, Feature Stability, and Resolution [J].

Derby, Brian .

ANNUAL REVIEW OF MATERIALS RESEARCH, VOL 40, 2010, 40 :395-414

[9] Understanding release kinetics of biopolymer drug delivery microcapsules for biomedical applications [J].

Desai, Salil ;

Perkins, Jessica ;

Harrison, Benjamin S. ;

Sankar, Jag .

MATERIALS SCIENCE AND ENGINEERING B-ADVANCED FUNCTIONAL SOLID-STATE MATERIALS, 2010, 168 (1-3) :127-131

[10] Microneedle-mediated intradermal nanoparticle delivery: Potential for enhanced local administration of hydrophobic pre-formed photosensitisers [J].

Donnelly, Ryan F. ;

Morrow, Desmond I. J. ;

Fay, Francois ;

Scott, Christopher J. ;

Abdelghany, Sharif ;

Singh, Raghu Raj Thakur ;

Garland, Martin J. ;

Woolfson, A. David .

PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY, 2010, 7 (04) :222-231

← 1 2 3 4 5 →