Transition metal-based lewis acid catalyzed ring opening of epoxides using amines under solvent-free conditions

被引：93

作者：

Zhao, PQ ^{[1
]}

Xu, LW ^{[1
]}

Xia, CG ^{[1
]}

机构：

[1] Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Peoples R China

来源：

SYNLETT | 2004年 / 05期

关键词：

amino alcohols; amines; epoxides; Lewis acids; solvent-free;

D O I：

10.1055/s-2004-817780

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Transition metal-based Lewis acids, such as SnCl,.5H(2)O, Co(OAc)(2).4H(2)O, Ni(OAc)(2).2H(2)O, NiCl2, Mn(OAc)(2).4H(2)O etc. catalyze the nucleophilic opening of epoxide rings by amines leading to the efficient synthesis of P-amino alcohols. The reaction works well with aromatic and aliphatic amines in high yields under solvent-free conditions.

引用

页码：846 / 850

页数：5

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