Talking about a revolution: The impact of site-specific recombinases on genetic analyses in mice

被引：618

作者：

Branda, CS ^{[1
]}

Dymecki, SM ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA

来源：

DEVELOPMENTAL CELL | 2004年 / 6卷 / 01期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S1534-5807(03)00399-X

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Site-specific recombinase systems (Cre-IoxP, Flp-FRT, and phiC31-att) are transforming both forward and reverse genetics in mice. By enabling high-fidelity DNA modifications to be induced in vitro or in vivo, these systems have incited a wave of new biology, advancing our understanding of gene function, genetic relationships, development, and disease.

引用

页码：7 / 28

页数：22

共 202 条

[1] Cre-mediated somatic site-specific recombination in mice
Akagi, K
Sandig, V
Vooijs, M
VanderValk, M
Giovannini, M
Strauss, M
Berns, A
[J]. NUCLEIC ACIDS RESEARCH, 1997, 25 (09) : 1766 - 1773
[2] SITE-SPECIFIC INTEGRATION OF DNA INTO WILD-TYPE AND MUTANT LOX SITES PLACED IN THE PLANT GENOME
ALBERT, H
DALE, EC
LEE, E
OW, DW
[J]. PLANT JOURNAL, 1995, 7 (04) : 649 - 659
[3] SYNAPSIS, STRAND SCISSION, AND STRAND EXCHANGE INDUCED BY THE FLP RECOMBINASE - ANALYSIS WITH HALF-FRT SITES
AMIN, A
ROCA, H
LUETKE, K
SADOWSKI, PD
[J]. MOLECULAR AND CELLULAR BIOLOGY, 1991, 11 (09) : 4497 - 4508
[4] Angrand P O, 1999, Nucleic Acids Res, V27, pe16, DOI 10.1093/nar/27.17.e16
[5] Targeted integration of DNA using mutant lox sites in embryonic stem cells
Araki, K
Araki, M
Yamamura, KI
[J]. NUCLEIC ACIDS RESEARCH, 1997, 25 (04) : 868 - 872
[6] Araki K, 1999, CELL MOL BIOL, V45, P737
[7] Focal activation of a mutant allele defines the role of stem cells in mosaic skin disorders
Arin, MJ
Longley, MA
Wang, XJ
Roop, DR
[J]. JOURNAL OF CELL BIOLOGY, 2001, 152 (03) : 645 - 649
[8] SITE-DIRECTED POINT MUTATIONS IN EMBRYONIC STEM-CELLS - A GENE-TARGETING TAG-AND-EXCHANGE STRATEGY
ASKEW, GR
DOETSCHMAN, T
LINGREL, JB
[J]. MOLECULAR AND CELLULAR BIOLOGY, 1993, 13 (07) : 4115 - 4124
[9] Cryptic boundaries in roof plate and choroid plexus identified by intersectional gene activation
Awatramani, R
Soriano, P
Rodriguez, C
Mai, JJ
Dymecki, SM
[J]. NATURE GENETICS, 2003, 35 (01) : 70 - 75
[10] An Flp indicator mouse expressing alkaline phosphatase from the ROSA26 locus
Awatramani, R
Soriano, P
Mai, JJ
Dymecki, S
[J]. NATURE GENETICS, 2001, 29 (03) : 257 - 259

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