The p38 signal transduction pathway - Activation and function

被引：1506

作者：

Ono, K ^{[1
]}

Han, JH ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Immunol, La Jolla, CA 92037 USA

来源：

CELLULAR SIGNALLING | 2000年 / 12卷 / 01期

关键词：

MAPK; p38; signalling;

D O I：

10.1016/S0898-6568(99)00071-6

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The p38 signalling transduction pathway, a Mitogen-activated protein (MAP) kinase pathway, plays an essential role in regulating many cellular processes including inflammation, cell differentiation, cell growth and death. Activation of p38 often through extracellular stimuli such as bacterial pathogens and cytokines, mediates signal transduction into the nucleus to turn on the responsive genes. p38 also transduces signals to other cellular components to execute different cellular responses. In this review, we summarize the characteristics of the major components of the p38 signalling transduction pathway and highlight the targets of this pathway and the physiological function of the p38 activation. (C) 2000 Elsevier Science Inc. All rights reserved.

引用

页码：1 / 13

页数：13

共 175 条

[1] Stimulation of α1A-adrenoceptors in rat-1 cells inhibits extracellular signal-regulated kinase by activating p38 mitogen-activated protein kinase [J].