Non-hydrogen-bonded secondary structure in β-peptides:: Evidence from circular dichroism of (S)-pyrrolidine-3-carboxylic acid oligomers and (S)-nipecotic acid oligomers

被引：61

作者：

Huck, BR ^{[1
]}

Langenhan, JM ^{[1
]}

Gellman, SH ^{[1
]}

机构：

[1] Univ Wisconsin, Dept Chem, Madison, WI 53706 USA

来源：

ORGANIC LETTERS | 1999年 / 1卷 / 11期

关键词：

D O I：

10.1021/ol9909482

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] Homooligomers of beta-amino acids (S)-3-pyrrolidine-3-carboxylic acid (PCA) and (S) nipecotic acid (Nip) were studied by circular dichroism (CD) in methanol. In each series, a profound change in the far UV CD spectrum was observed from monomer to tetramer, but little change was observed from tetramer to hexamer. A comparable pattern is observed in the CD spectra of short proline oligomers. We conclude that both PCA and Nip oligomers with greater than or equal to four residues adopt a characteristic secondary structure.

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页码：1717 / 1720

页数：4

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