Hypothyroidism prolongs mitotic activity in the post-natal mouse brain

被引：83

作者：

Hadj-Sahraoui, N ^{[1
]}

Seugnet, I ^{[1
]}

Ghorbel, MT ^{[1
]}

Demeneix, B ^{[1
]}

机构：

[1] Museum Natl Hist Nat, CNRS, UMR 8572, Lab Physiol Gen & Comparee, F-75231 Paris 5, France

来源：

NEUROSCIENCE LETTERS | 2000年 / 280卷 / 02期

关键词：

mitosis; thyroid hormones; mouse; central nervous system; neonatal period; progenitors;

D O I：

10.1016/S0304-3940(00)00768-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Circulating T-4 and T-3 were measured during the first three post-natal weeks in the mouse and found to increase in a triphasic manner. The first increase occurred at post-natal day 6 and was simultaneous with a decrease in bromodeoxyuridine incorporation in areas showing post-natal mitosis. We investigated whether there was a causal relationship between increased thyroid hormone levels and decreased proliferation by inducing hypothyroidism in darns and progeny. Hypothyroidism prolonged mitotic activity in the olfactory bulb, hippocampus, subventricular zone and the cerebellar cortex. This suggests that the increase in T-3 at the end of the first postnatal week is implicated in terminating progenitor proliferation in many parts of the mouse brain. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：79 / 82

页数：4

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