cIAP Proteins: Keystones in NOD Receptor Signal Transduction

被引：10

作者：

Reardon, Colin ^{[1
]}

Mak, Tak W. ^{[1
]}

机构：

[1] Princess Margaret Hosp, Campbell Family Canc Res Inst, Toronto, ON M5G 2C1, Canada

来源：

IMMUNITY | 2009年 / 30卷 / 06期

关键词：

ACTIVATION; POLYUBIQUITINATION; DISEASE;

D O I：

10.1016/j.immuni.2009.06.005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

NOD1 and 2 are intracellular sentinels critical to innate immunity. In this issue of Immunity, Bertrand et al. (2009) fill in a gap in the NOD signaling cascade by demonstrating that cIAP1 and 2 function as E3 ubiquitin ligases for the RIP2 signaling molecule.

引用

页码：755 / 756

页数：2

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