Functional MRI Evidence for LTP-Induced Neural Network Reorganization

被引:82
作者
Canals, Santiago [1 ]
Beyerlein, Michael [1 ]
Merkle, Hellmut [3 ]
Logothetis, Nikos K. [1 ,2 ]
机构
[1] Max Planck Inst Biol Cybernet, D-72076 Tubingen, Germany
[2] Univ Manchester, Manchester M13 9PL, Lancs, England
[3] NINDS, Lab Funct & Mol Imaging, NIH, Bethesda, MD 20892 USA
关键词
LONG-TERM POTENTIATION; SYNAPTIC-TRANSMISSION; PYRAMIDAL CELLS; NMDA RECEPTORS; HIPPOCAMPUS; FMRI; STIMULATION; EXPRESSION; PATHWAY; CORTEX;
D O I
10.1016/j.cub.2009.01.037
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The hippocampal formation is a region of the forebrain that is important for memory and spatial navigation [1, 2]. On the basis of a vast amount of literature, the hippocampus is linked with long-term potentiation (LTP), the increased synaptic strength following repeated stimulation of the hippocampal neurons [3, 4]. LTP is considered to be the experimental demonstration of Hebb's postulate on synaptic strength and learning [5], and it is the dominant model of an experience-dependent modification of brain circuits. Yet, despite the importance of this phenomenon for brain physiology and behavior, little is known about how experimentally measured regional synaptic modifications alter the activity of global, widespread networks. Here, we use simultaneous fMRI, microstimulation, and electrophysiology [6-8] to unveil global changes in brain activity due to local hippocampal plasticity. Our findings offer the first evidence of an LTP-induced network reorganization that includes increased interhemispheric communication and recruitment of limbic and neocortical circuits after changes in synaptic strength within the hippocampus.
引用
收藏
页码:398 / 403
页数:6
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