Connexin 43 and ischemic preconditioning: effects of age and disease

被引：29

作者：

Boengler, Kerstin ^{[1
]}

Heusch, Gerd ^{[1
]}

Schulz, Rainer ^{[1
]}

机构：

[1] Univ Essen Gesamthsch Klinikum, Inst Pathophysiol, Zentrum Innere Med, D-45122 Essen, Germany

来源：

EXPERIMENTAL GERONTOLOGY | 2006年 / 41卷 / 05期

关键词：

connexin; 43; ischemic preconditioning; aging;

D O I：

10.1016/j.exger.2006.01.011

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Connexin 43 (Cx43) is the constitutive protein for the formation of cardiac gap junctions and therefore essential for cell-cell coupling and normal cardiac function. Apart from its localization at the sarcolemma, Cx43 is present in the inner mitochondrial membrane. Cx43 is involved in cardiomyocyte free oxygen radical formation and in the cardioprotection by ischemic preconditioning (IP). This review will discuss Cx43 deficiency in aged and diseased myocardium and the potential impact of age and disease on IP's cardioprotection. (c) 2006 Elsevier Inc. All rights reserved.

引用

页码：485 / 488

页数：4

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