Origins of HIV and the evolution of resistance to AIDS

被引：115

作者：

Heeney, Jonathan L. ^{[1
]}

Dalgleish, Angus G.

Weiss, Robin A.

机构：

[1] Biomed Primate Res Ctr, Dept Virol, NL-2280 GH Rijswijk, Netherlands

[2] Univ London St Georges Hosp, Sch Med, Dept Cellular & Mol Med, Div Oncol, London SW17 0RE, England

[3] UCL, Wohl Vir Ctr, Div Infect & Immun, London W1T 4JF, England

来源：

SCIENCE | 2006年 / 313卷 / 5786期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1126/science.1123016

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The cross-species transmission of lentiviruses from African primates to humans has selected viral adaptations which have subsequently facilitated human-to-human transmission. HIV adapts not only by positive selection through mutation but also by recombination of segments of its genome in individuals who become multiply infected. Naturally infected nonhuman primates are relatively resistant to AIDS-like disease despite high plasma viral loads and sustained viral evolution. Further understanding of host resistance factors and the mechanisms of disease in natural primate hosts may provide insight into unexplored therapeutic avenues for the prevention of AIDS.

引用

页码：462 / 466

页数：5

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