Conjugated linoleic acid and the control of cancer and obesity

被引：98

作者：

Pariza, MW ^{[1
]}

Park, Y ^{[1
]}

Cook, ME ^{[1
]}

机构：

[1] Univ Wisconsin, Dept Food Microbiol & Toxicol, Food Res Inst, Madison, WI 53706 USA

来源：

TOXICOLOGICAL SCIENCES | 1999年 / 52卷 / 02期

关键词：

conjugated linoleic acid; body composition; cytokines; tumor necrosis factor-alpha;

D O I：

10.1093/toxsci/52.suppl_1.107

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

The effects of conjugated linoleic acid (CLA) in animals are reviewed. In most of the CLA preparations that have been investigated to date for biological activity, two CLA isomers are present in about equal concentrations: cis-9,trans-11 CLA, and trans-10,cis-12 CLA. The occurrence of these isomers in foods and their production by rumen microorganisms are discussed. Potential mechanisms of action as regards the effects of CLA on cancer and body composition are reviewed, including recent evidence that body composition changes are produced by the trans-10,cis-12 CLA isomer. Evidence is presented indicating that CLA may modulate cellular response to tumor necrosis factor-alpha (TNF-alpha). The mechanistic implications of this finding are considered.

引用

页码：107 / 110

页数：4

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