Mesenchymal stem cells in immunoregulation

被引：167

作者：

Chen, Xi

Armstrong, Marilyn Ann

Li, Gang

机构：

[1] Queens Univ Belfast, Sch Biomed Sci, Dept Orthopaed Surg, Belfast BT9 7JB, Antrim, North Ireland

[2] Queens Univ Belfast, Royal Victoria Hosp Trust, Ctr Canc Res & Cell Biol, Dept Microbiol & Immunol, Belfast BT9 7JB, Antrim, North Ireland

来源：

IMMUNOLOGY AND CELL BIOLOGY | 2006年 / 84卷 / 05期

关键词：

dendritic cell; immunoregulation; immunosuppression; mesenchymal stem cell; T cell;

D O I：

10.1111/j.1440-1711.2006.01458.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Mesenchymal stem cells are present within the bone marrow cavity and serve as a reservoir for the continuous renewal of various mesenchymal tissues. Recent studies suggest that mesenchymal stem cells modulate immune reactions in vitro and escape from immune surveillance in vivo. We provide herein a discussion of issues including the current research progress on the in vitro interactions of mesenchymal stem cells with multiple subsets of immune cells (dendritic cells, T cells, B cells and NK cells), in vivo transplantation outcomes, the possible underlying mechanisms, future research directions as well as potential clinical implications.

引用

收藏

页码：413 / 421

页数：9

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