The structure of a stable intermediate in the A ⇆ B DNA helix transition

被引：100

作者：

Ng, HL ^{[1
]}

Kopka, ML ^{[1
]}

Dickerson, RE ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Inst Mol Biol, Los Angeles, CA 90095 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2000年 / 97卷 / 05期

关键词：

D O I：

10.1073/pnas.040571197

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The DNA dodecamer CATGGGCCCATG in a crystal structure of resolution 1.3 Angstrom has a conformation intermediate between A and B DNA. This trapping of a stable intermediate suggests that the A and B DNA families are not discrete, as previously believed. The structure supports a base-centered rather than a backbone-centered mechanism for the A <-> B transition mediated by guanine tracts. Interconversion between A and B DNA provides another means for regulating protein-DNA recognition.

引用

页码：2035 / 2039

页数：5

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