Cerebral perfusion in the predementia stages of Alzheimer's disease

被引：104

作者：

Binnewijzend, Maja A. A. ^{[1
]}

Benedictus, Marije R. ^{[2
]}

Kuijer, Joost P. A. ^{[3
]}

van der Flier, Wiesje M. ^{[2
,4
]}

Teunissen, Charlotte E. ^{[5
]}

Prins, Niels D. ^{[2
]}

Wattjes, Mike P. ^{[1
]}

van Berckel, Bart N. M. ^{[1
]}

Scheltens, Philip ^{[2
]}

Barkhof, Frederik ^{[1
]}

机构：

[1] Vrije Univ Amsterdam, Alzheimerctr Amsterdam, Dept Radiol & Nucl Med, Med Ctr, Neurosci Campus Amsterdam,POB 7057, NL-1007 MB Amsterdam, Netherlands

[2] Vrije Univ Amsterdam, Alzheimer Ctr Amsterdam, Dept Neurol, Med Ctr, Neurosci Campus Amsterdam,POB 7057, NL-1007 MB Amsterdam, Netherlands

[3] Vrije Univ Amsterdam, Alzheimer Ctr Amsterdam, Dept Phys & Med Technol, Med Ctr, Neurosci Campus Amsterdam,POB 7057, NL-1007 MB Amsterdam, Netherlands

[4] Vrije Univ Amsterdam, Alzheimer Ctr Amsterdam, Dept Epidemiol & Biostat, Med Ctr, Neurosci Campus Amsterdam,POB 7057, NL-1007 MB Amsterdam, Netherlands

[5] Vrije Univ Amsterdam, Alzheimer Ctr Amsterdam, Dept Clin Chem, Med Ctr, Neurosci Campus Amsterdam,POB 7057, NL-1007 MB Amsterdam, Netherlands

来源：

EUROPEAN RADIOLOGY | 2016年 / 26卷 / 02期

基金：

欧盟第七框架计划;

关键词：

Arterial spin-labelling MRI; Cerebral blood flow/cerebral perfusion; Alzheimer's disease; Prodromal AD; Disease progression; MILD COGNITIVE IMPAIRMENT; ASSOCIATION WORKGROUPS; DIAGNOSTIC GUIDELINES; NATIONAL INSTITUTE; BLOOD-FLOW; HYPOTHETICAL MODEL; DYNAMIC BIOMARKERS; LEWY BODIES; DEMENTIA; MRI;

D O I：

10.1007/s00330-015-3834-9

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Objectives To investigate arterial spin-labelling (ASL) cerebral blood flow (CBF) changes in predementia stages of Alzheimer's disease (AD). Methods Data were obtained from 177 patients with subjective complaints, mild cognitive impairment and AD from the Amsterdam Dementia Cohort. AD stages were based on diagnosis and cerebrospinal fluid biomarkers amyloid-beta (A beta) and total-tau (tau). General-linear-models were used to assess relationships between AD stages and total and regional CBF, correcting for age and sex. Results Decreasing CBF was related to more advanced AD stages in all supratentorial regions (p for trend < 0.05). Post-hoc testing revealed that CBF was lower in AD compared to controls and stage-1 predementia patients (i.e. abnormal A beta and normal tau) in temporal and parietal regions, and compared to stage-2 predementia patients (i.e. abnormal A beta and tau) in temporal regions. CBF values of stage-2 predementia patients were numerically in between those of stage-1 predementia patients and AD. Conclusion The continuing decrease of CBF along the continuum of AD indicates the potential of ASL-CBF as a measure for disease progression.

引用

页码：506 / 514

页数：9

共 34 条

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