High Rate of HIV Resuppression After Viral Failure on First-line Antiretroviral Therapy in the Absence of Switch to Second-line Therapy

被引：35

作者：

Gupta, Ravindra K. ^{[1
]}

Goodall, Ruth L. ^{[2
]}

Ranopa, Michael ^{[2
]}

Kityo, Cissy ^{[3
]}

Munderi, Paula ^{[4
]}

Lyagoba, Fred ^{[4
]}

Mugarura, Lincoln ^{[3
]}

Gilks, Charles F. ^{[5
]}

Kaleebu, Pontiano ^{[4
]}

Pillay, Deenan ^{[1
,6
]}

机构：

[1] UCL, Dept Infect, London WC1E 6BT, England

[2] UCL, Med Res Council MRC Clin Trials Unit, London WC1E 6BT, England

[3] Joint Clin Res Ctr, Kampala, Uganda

[4] MRC Uganda Virus Res Inst, Uganda Res Unit AIDS, Entebbe, Uganda

[5] Univ Queensland, Sch Populat Hlth, Brisbane, Qld, Australia

[6] Univ KwaZulu Natal, Wellcome Trust Africa Ctr Hlth & Populat Sci, Mtubatuba, South Africa

来源：

CLINICAL INFECTIOUS DISEASES | 2014年 / 58卷 / 07期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

HIV; failure; viral resuppression; resistance; Africa; INFECTED UGANDAN ADULTS; RESISTANCE; MUTATIONS; COMBINATION; ZIDOVUDINE; PATTERNS;

D O I：

10.1093/cid/cit933

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In a randomized comparison of nevirapine or abacavir with zidovudine plus lamivudine, routine viral load monitoring was not performed, yet 27% of individuals with viral failure at week 48 experienced resuppression by week 96 without switching. This supports World Health Organization recommendations that suspected viral failure should trigger adherence counseling and repeat measurement before a treatment switch is considered.

引用

页码：1023 / 1026

页数：4

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