Interleukin-6 production by human monocytes stimulated with Cryptococcus neoformans components

被引：45

作者：

Delfino, D ^{[1
]}

Cianci, L ^{[1
]}

Lupis, E ^{[1
]}

Celeste, A ^{[1
]}

Petrelli, ML ^{[1
]}

Curro, F ^{[1
]}

Cusumano, V ^{[1
]}

Teti, G ^{[1
]}

机构：

[1] UNIV MESSINA,FAC MED & CHIRURG,IST MICROBIOL,I-98122 MESSINA,ITALY

来源：

INFECTION AND IMMUNITY | 1997年 / 65卷 / 06期

关键词：

D O I：

10.1128/IAI.65.6.2454-2456.1997

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In order to ascertain if Cryptococcus neoformans components can induce interleukin-6 (IL-6) production, we stimulated human whole blood with purified capsular products. Their potencies in stimulating IL-G release were mannoproteins > galactoxylomannan = glucuronoxylomannan > alpha(1-3)glucan. IL-6 production was tumor necrosis factor alpha independent and required the presence of monocytes and plasma. Since IL-6 can stimulate replication of the human immunodeficiency virus ire monocytic cells, these findings may he clinically relevant.

引用

页码：2454 / 2456

页数：3

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