Treatment and transfer of emphysema by a new bone marrow transplantation method from normal mice to Tsk mice and vice versa

被引：27

作者：

Adachi, Yasushi

Oyaizu, Haruki

Taketani, Shigeru

Minamino, Keizo

Yamaguchi, Kazuyuki

Shultz, Leonard D.

Iwasaki, Masayoshi

Tomita, Minoru

Suzuki, Yasuhiro

Nakano, Keiji

Koike, Yasushi

Yasumizua, Ryoji

Sata, Makoto

Hirama, Noriyuki

Kubota, Isao

Fukuhara, Shirou

Ikehara, Susumu ^{[1
]}

机构：

[1] Kansai Med Univ, Dept Pathol 1, Moriguchi, Osaka 5700023, Japan

[2] Kansai Med Univ, Transplant Ctr, Moriguchi, Osaka 5700023, Japan

[3] Kansai Med Univ, Dept Internal Med 1, Moriguchi, Osaka 5700023, Japan

[4] Kyoto Inst Technol, Dept Biotechnol, Sakyo Ku, Kyoto 606, Japan

[5] Jackson Lab, Bar Harbor, ME 04609 USA

[6] Yamagata Univ, Sch Med, Dept Internal Med 1, Yamagata 99023, Japan

来源：

STEM CELLS | 2006年 / 24卷 / 09期

关键词：

emphysema; treatment; tight-skin mice; intrabone marrow-bone marrow transplantation;

D O I：

10.1634/stemcells.2005-0575

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

We have recently established a new bone marrow transplantation (BMT) method in which bone marrow cells are injected into the intrabone marrow (IBM). In the present study, we used an animal model for emphysema (tight-skin [Tsk] mouse) to examine whether IBM-BMT could be used to treat emphysema in Tsk mice. IBM-BMT was carried out from C3H mice into Tsk mice (8-10 weeks old) that had already shown emphysema. Six months after transplantation, the lungs of all the Tsk mice treated with IBM-BMT [C3H -> Tsk] showed similar structures to those of normal mice, whereas the [Tsk -> Tsk] mice showed emphysema, as seen in age-matched Tsk mice. Next, we attempted to transfer emphysema from Tsk mice to C3H mice by IBM-BMT. Six months after IBM-BMT, the [Tsk -> C3H] mice showed emphysema. These results strongly suggest that emphysema in Tsk mice originates from defects of stem cells in the bone marrow.

引用

页码：2071 / 2077

页数：7

共 35 条

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