ent-Trachyloban-3β-ol, a new cytotoxic diterpene from Croton zambesicus

被引：59

作者：

Block, S

Stévigny, C

De Pauw-Gillet, MC

de Hoffmann, E

Llabrèes, G

Adjakidjé, V

Quetin-Leclercq, J

机构：

[1] Univ Catholique Louvain, Lab Pharmacognosie, Unite Anal Chim & Physicochim Med 72 30, B-1200 Brussels, Belgium

[2] Univ Liege, CRCE, Liege, Belgium

[3] Univ Catholique Louvain, Lab Spectrometrie Masse, B-1348 Louvain, Belgium

[4] Univ Liege, Dept Phys Expt, Liege, Belgium

[5] Univ Natl Benin, Fac Sci & Tech, Dept Biol Vegetal, Abomey Calavy, Benin

来源：

PLANTA MEDICA | 2002年 / 68卷 / 07期

关键词：

D O I：

10.1055/s-2002-32903

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The dichloromethane extract of leaves of Croton zambesicus (Euphorbiaceae) showing in vitro cytotoxicity against human cervix carcinoma cells was investigated in order to identify its active compounds. A bio-guided fractionation by HSCCC followed by MPLC led us to isolate a trachylobane diterpene, ent-trachyloban-3beta-ol, with cytotoxic properties (IC50 on HeLa cells = 7.3 mug/ml). This is the first report on the cytotoxicity of a trachylobane diterpene.

引用

页码：647 / 649

页数：3

共 9 条

[1]

ADJANOHOUN EJ, 1989, CONTRIBUTION ETUDES, V1, P245

[2] C-13 NMR-SPECTROSCOPY OF NATURAL SUBSTANCES .4. C-13 NMR-STUDIES OF TRACHYLOBANE DITERPENES - COMPLETE CARBON ASSIGNMENT [J].

ARNONE, A ;

MONDELLI, R ;

PYREK, JS .

ORGANIC MAGNETIC RESONANCE, 1979, 12 (07) :429-431

[3] THE TRACHYLOBANE DITERPENES [J].

FRAGA, BM .

PHYTOCHEMICAL ANALYSIS, 1994, 5 (02) :49-56

[4] KAURANE AND TRACHYLOBANE DITERPENES FROM XYLOPIA-AETHIOPICA [J].

HARRIGAN, GG ;

BOLZANI, VD ;

GUNATILAKA, AAL ;

KINGSTON, DGI .

PHYTOCHEMISTRY, 1994, 36 (01) :109-113

[5] Anti-tumor effects of d-dicentrine from the root of Lindera megaphylla [J].

Huang, RL ;

Chen, CC ;

Huang, YL ;

Ou, JC ;

Hu, CP ;

Chen, CF ;

Chang, CM .

PLANTA MEDICA, 1998, 64 (03) :212-215

[6] Diterpenoids from the roots of Croton macrostachys [J].

Kapingu, MC ;

Guillaume, D ;

Mbwambo, ZH ;

Moshi, MJ ;

Uliso, FC ;

Mahunnah, RLA .

PHYTOCHEMISTRY, 2000, 54 (08) :767-770

[7] ent-trachylobane diterpenoids from the liverwort Mastigophora diclados [J].

Leong, YW ;

Harrison, LJ .

PHYTOCHEMISTRY, 1997, 45 (07) :1457-1459

[8] DITERPENES FROM THE FRUITS OF XYLOPIA-AROMATICA [J].

MORAES, MPL ;

ROQUE, NF .

PHYTOCHEMISTRY, 1988, 27 (10) :3205-3208

[9] Crotonadiol, a labdane diterpenoid from the stem bark of Croton zambesicus [J].

Ngadjui, BT ;

Folefoc, GG ;

Keumedjio, F ;

Dongo, E ;

Sondengam, BL ;

Connolly, JD .

PHYTOCHEMISTRY, 1999, 51 (01) :171-174

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