Scar collagen deposition in the airways of allografts of lung transplant recipients

被引:37
作者
Zheng, L [1 ]
Ward, C [1 ]
Snell, GI [1 ]
Orsida, BE [1 ]
Li, X [1 ]
Wilson, JW [1 ]
Williams, TJ [1 ]
Walters, EH [1 ]
机构
[1] ALFRED HOSP,MONASH MED SCH,DEPT RESP MED,RESP IMMUNOL GRP,MELBOURNE,VIC 3181,AUSTRALIA
关键词
CRYPTOGENIC FIBROSING ALVEOLITIS; OBLITERATIVE BRONCHIOLITIS; PULMONARY FIBROSIS; V COLLAGEN; DISEASE; INVITRO;
D O I
10.1164/ajrccm.155.6.9196117
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
Collagen subtype deposition has not been studied in the airways of transplanted lungs. As part of rejection, a series of immunologic insults results in a remodeling of the allograft. In chronic rejection, changes in the airway leading to obliterative bronchiolitis syndrome (OBS) are particularly important. To better understand the mechanism of OBS occurring in chronic lung rejection, we investigated deposition of three fibrillar collagens (type I, III, V) in airway biopsies of lung allograft; taken from 10 clinically well lung transplant recipients (wLTR) and eight lung transplant recipients (LTR) with OBS (OBLTR) using an immunoperoxidase method. Collagen III deposition and the ratio of collagen type III to type I were found to be significantly increased in OBLTR compared with wLTR (p < 0.05), and the latter correlated inversely with both FEF25-75 (r = -0.69; p < 0.05) and FEV1 (r = 0.62; p = 0.05) in OBLTR. This suggests that an increased proportion of collagen III in the airway walls of transplanted lungs might be an early signal of the progression to terminal chronic lung allograft dysfunction. The changes in the ratio of type III to type I collagen in the airways of lung allografts may provide important insights into the process of airway remodeling in chronic lung rejection.
引用
收藏
页码:2072 / 2077
页数:6
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