Protective effect of melatonin on 3-nitropropionic acid-induced oxidative stress in synaptosomes in an animal model of Huntington's disease

被引：115

作者：

Túnez, I ^{[1
]}

Montilla, P ^{[1
]}

Muñoz, MD ^{[1
]}

Feijóo, M ^{[1
]}

Salcedo, M ^{[1
]}

机构：

[1] Univ Cordoba, Sch Med, Dept Biochem & Mol Biol, E-14004 Cordoba, Spain

来源：

JOURNAL OF PINEAL RESEARCH | 2004年 / 37卷 / 04期

关键词：

3-nitropropionic acid; free radical scavenger; Huntington's disease; melatonin; oxidative stress; synaptosomes;

D O I：

10.1111/j.1600-079X.2004.00163.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The effect of melatonin (1 mg/kg BW i.p./day) on the oxidative changes produced by 3-nitropropionic acid (20 mg/kg BW/day for 4 days) in rat striatal and cortical synaptosomes was investigated. The effects of 3-nitropropionic acid were evaluated as changes in the quantity of lipid peroxidation products, protein carbonyl groups and superoxide dismutase and succinate dehydrogenase activities. 3-Nitropropionic acid caused a rise in lipid peroxidation levels and protein carbonyls content whereas it induced a reduction in the activity of succinate dehydrogenase and triggered an enhancement in superoxide dismutase activity. These changes were prevented by previous administration of melatonin. Our results reveal: (i) 3-nitropropionic acid induces a status of oxidative stress in some brain regions of the Wistar rat; (ii) melatonin prevents the deleterious effects induced by the acid. In conclusion, the results show the ability of melatonin to modify the neural response to 3-nitropropionic acid with the protective mechanism likely involving the antioxidative processes of melatonin.

引用

页码：252 / 256

页数：5

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