Mutation of the mouse klotho gene leads to a syndrome resembling ageing

被引：3311

作者：

Kuroo, M

Matsumura, Y

Aizawa, H

Kawaguchi, H

Suga, T

Utsugi, T

Ohyama, Y

Kurabayashi, M

Kaname, T

Kume, E

Iwasaki, H

Iida, A

ShirakiIida, T

Nishikawa, S

Nagai, R

Nabeshima, Y

机构：

[1] GUNMA UNIV,SCH MED,DEPT INTERNAL MED 2,SHOWA KU,MAEBASHI,GUMMA 371,JAPAN

[2] UNIV TOKYO,FAC MED,DEPT ORTHOPAED SURG,BUNKYO KU,TOKYO 113,JAPAN

[3] KUMAMOTO UNIV,SCH MED,INST MOL EMBRYOL & GENET,KUMAMOTO 862,JAPAN

[4] TANABE SEIYAKU CO LTD,LEAD OPTIMIZAT RES LAB,TODA,SAITAMA 335,JAPAN

[5] KYOWA HAKKO KOGYO CO LTD,TOKYO RES LABS,MACHIDA,TOKYO 194,JAPAN

[6] KYOWA HAKKO KOGYO CO LTD,PHARMACEUT RES LABS,NAGAIZUMI,SHIZUOKA 411,JAPAN

[7] JRDC,CREST,SUITA,OSAKA 565,JAPAN

[8] OSAKA UNIV,INST MOL & CELLULAR BIOL,SUITA,OSAKA 565,JAPAN

来源：

NATURE | 1997年 / 390卷 / 6655期

关键词：

D O I：

10.1038/36285

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 [理学]; 0710 [生物学]; 09 [农学];

摘要：

A new gene, termed klotho, has been identified that is involved in the suppression of several ageing phenotypes. A defect in klotho gene expression in the mouse results in a syndrome that resembles human ageing, Including a short lifespan, infertility, arteriosclerosis, skin atrophy, osteoporosis and emphysema. The gene encodes a membrane protein that shares sequence similarity with the B-glucosidase enzymes. The klotho gene product may function as part of a signalling pathway that regulates ageing in vivo and morbidity In age-related diseases.

引用

页码：45 / 51

页数：7

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