Total synthesis of (-)-lasubine II by the conjugate addition and intramolecular acylation of an amino ester with an acetylenic sulfone

被引：46

作者：

Back, TG ^{[1
]}

Hamilton, MD ^{[1
]}

机构：

[1] Univ Calgary, Dept Chem, Calgary, AB T2N 1N4, Canada

来源：

ORGANIC LETTERS | 2002年 / 4卷 / 10期

关键词：

D O I：

10.1021/ol0258482

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] The conjugate addition of methyl (S)-(2-piperidyl)acetate (3) to 2-(3,4-dimethoxyphenyl)-1-(p-toluenesulfonyl)ethyne (4), followed by LDA-promoted intramolecular acylation, stereoselective reduction, and desulfonylation, afforded (-)-lasubine II.

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页码：1779 / 1781

页数：3

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