TNF-related apoptosis-inducing ligand: Signalling of a 'smart' molecule

被引：25

作者：

Manzo, Fabio ^{[1
,2
]}

Nebbioso, Angela ^{[1
]}

Miceli, Marco ^{[1
]}

Conte, Mariarosaria ^{[1
]}

De Bellis, Floriana ^{[1
,2
]}

Carafa, Vincenzo ^{[1
]}

Franci, Gianluigi ^{[1
]}

Tambaro, Francesco P. ^{[3
,4
]}

Altucci, Lucia ^{[1
]}

机构：

[1] Univ Naples 2, Dipartimento Patol Gen, Naples, Italy

[2] Dept Canc Biol, IGBMC, F-67404 Illkirch Graffenstaden, France

[3] Univ Naples 2, Dipartimento Flaviano Magrassi, Naples, Italy

[4] Osped Antonio Cardarelli, Sez Ematol, Naples, Italy

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2009年 / 41卷 / 03期

关键词：

TRAIL; Cancer; Apoptosis; Signalling; Receptors; NF-KAPPA-B; CELL-DEATH; TUMOR-CELLS; TRAIL; RECEPTOR; APO2L/TRAIL; INHIBITION; SENSITIVITY; EXPRESSION; HEAT-SHOCK-PROTEIN-90;

D O I：

10.1016/j.biocel.2007.12.012

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the tumor necrosis factor super-family and signals via two death receptors, TRAIL-R1 and TRAIL-R2, and two decoy receptors, TRAIL-R3 and TRAIL-R4, differently expressed in normal and cancer cells. TRAIL is mainly studied for its capacity to induce apoptosis preferentially in cancer cells. TRAIL is expressed in a variety of human tissues, in particular in the lymphoid system, suggesting a strong physiological role in the innate immunity. This review will focus on TRAIL gene structure and regulation, protein folding, tissue expression and molecular signalling. Finally, the potential use of TRAIL as anticancer treatment alone or in combination therapy as well as the use of drugs which signal via TRAIL and its receptors will be analyzed. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：460 / 466

页数：7

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