Comparison of radiation effects of gadolinium and boron neutron capture reactions

被引:17
作者
Tokuuye, K
Tokita, N
Akine, Y
Nakayama, H
Sakurai, Y
Kobayashi, T
Kanda, K
机构
[1] Natl Canc Ctr Hosp, Div Radiat Oncol, Chuo Ku, Tokyo 1040045, Japan
[2] Univ Tsukuba, Tsukuba, Ibaraki 305, Japan
[3] Kyoto Univ, Inst Res Reactor, Osaka 59004, Japan
关键词
gadolinium; boron; neutron capture therapy;
D O I
10.1007/PL00002332
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Purpose: Cell survival assays were performed to evaluate the effects of radiations released during neutron capture reactions by gadolinium-157, boron-10 and by the combination of both. Materials and Methods: Single cell suspensions with or without Gd-157 and/or B-10 were ex-posed to thermal neutrons produced by the Kyoto University reactor, and standard cell survival curves were obtained. Results: Under the same molarity, cytocidal effects were 1.5 times greater for Gd-157 than for boron when compared at 10% survival levels. The presence of B-10 enhanced the radiation effect of Gd-157 neutron capture by 1.2-fold, suggesting that cells were not sufficiently irradiated as a result of neutron fluency attenuation by the presence of excess neutron capture agents in the medium. Conclusions: When an equal number of atoms were present, Gd-157 was effective as B-10 when exposed to an equal number of thermal neutrons. However, there was no benefit observed in the combination of Gd-157 and B-10 for neutron capture therapy. Further studies are needed to determine optimal Gd-157 and B-10 concentrations as a function of tumor dimension.
引用
收藏
页码:81 / 83
页数:3
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