Dual effect of IL-4 on resistance to systemic gram-negative infection and production of TNF-α

被引：16

作者：

Giampietri, A ^{[1
]}

Grohmann, U ^{[1
]}

Vacca, C ^{[1
]}

Fioretti, MC ^{[1
]}

Puccetti, P ^{[1
]}

Campanile, F ^{[1
]}

机构：

[1] Univ Perugia, Dept Expt Med, Pharmacol Sect, I-06126 Perugia, Italy

来源：

CYTOKINE | 2000年 / 12卷 / 04期

关键词：

IL-4; IL-12; septic shock; TNF-alpha;

D O I：

10.1006/cyto.1999.0576

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

To determine the effect of interleukin 4 (IL-4) administration in a live sepsis model characterised by high-level production of tumour necrosis factor alpha (TNF-alpha), mice infected systemically with lethal or sublethal inocula of Pseudomonas aeruginosa were given the recombinant cytokine at different times before infection. Improved survival and decreased TNF-alpha production mere observed in lethally infected mice treated with the cytokine 1 day before challenge. In contrast, increased mortality and overproduction of TNF-alpha were observed in sublethally infected mice given IL-4 at the time of infection, (C) 2000 Academic Press.

引用

页码：417 / 421

页数：5

共 15 条

[1] A RECOMBINANT HUMAN RECEPTOR ANTAGONIST TO INTERLEUKIN-1 IMPROVES SURVIVAL AFTER LETHAL ENDOTOXEMIA IN MICE [J].

ALEXANDER, HR ;

DOHERTY, GM ;

BURESH, CM ;

VENZON, DJ ;

NORTON, JA .

JOURNAL OF EXPERIMENTAL MEDICINE, 1991, 173 (04) :1029-1032

[2]

BANCHEREAU J, 1995, CYTOKINE HDB, P99

[3] A phenomenology of boundary lubrication: the lumped junction model [J].

Baumberger, T ;

Caroli, C .

EUROPEAN PHYSICAL JOURNAL B, 1998, 4 (01) :13-23

[4] Evidence for tumor necrosis factor alpha as a mediator of the toxicity of a cyclooxygenase inhibitor in Gram-negative sepsis [J].

Campanile, F ;

Giampietri, A ;

Grohmann, U ;

Belladonna, ML ;

Fioretti, MC ;

Puccetti, P .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1996, 307 (02) :191-199

[5] ANTIBACTERIAL RESISTANCE INDUCED BY RECOMBINANT INTERLEUKIN-1 IN MYELOSUPPRESSED MICE - EFFECT OF TREATMENT SCHEDULE AND CORRELATION WITH COLONY-STIMULATING ACTIVITY IN THE BLOOD-STREAM [J].

CAMPANILE, F ;

BINAGLIA, L ;

BORASCHI, D ;

TAGLIABUE, A ;

FIORETTI, MC ;

PUCCETTI, P .

CELLULAR IMMUNOLOGY, 1990, 128 (01) :250-260

[6]

CAMPANILE F, 1994, FUND CLIN IMMUNOL, V2, P97

[7] STIMULATORY AND INHIBITORY EFFECTS OF INTERLEUKIN (IL)-4 AND IL-13 ON THE PRODUCTION OF CYTOKINES BY HUMAN PERIPHERAL-BLOOD MONONUCLEAR-CELLS - PRIMING FOR IL-12 AND TUMOR-NECROSIS-FACTOR-ALPHA PRODUCTION [J].

DANDREA, A ;

MA, XJ ;

ASTEAMEZAGA, M ;

PAGANIN, C ;

TRINCHIERI, G .

JOURNAL OF EXPERIMENTAL MEDICINE, 1995, 181 (02) :537-546

[8]

DOHERTY GM, 1992, J IMMUNOL, V149, P1666

[9]

FINKELMAN FD, 1993, J IMMUNOL, V151, P1235

[10] INTERLEUKIN-12 IS PRODUCED IN-VIVO DURING ENDOTOXEMIA AND STIMULATES SYNTHESIS OF GAMMA-INTERFERON [J].

HEINZEL, FP ;

RERKO, RM ;

LING, P ;

HAKIMI, J ;

SCHOENHAUT, DS .

INFECTION AND IMMUNITY, 1994, 62 (10) :4244-4249

← 1 2 →