Azithromycin activities against Orientia tsutsugamushi strains isolated in cases of scrub typhus in northern Thailand

被引：32

作者：

Watt, G

Kantipong, P

Jongsakul, K

Watcharapichat, P

Phulsuksombati, D

机构：

[1] AFRIMS, USA Component, Dept Retrovirol, Bangkok, Thailand

[2] AFRIMS, Royal Thai Army Component, Analyt Div, Bangkok, Thailand

[3] Chiangrai Reg Hosp, Dept Med, Chingrai, Thailand

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1999年 / 43卷 / 11期

关键词：

D O I：

10.1128/AAC.43.11.2817

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Azithromycin was given to mice and humans infected with strains of Orientia tsutsugamushi from northern Thailand, where drug-resistant scrub typhus occurs. Azithromycin and doxycycline yielded comparable mouse survival rates (73 and 79%, respectively; P > 0.5). Symptoms, signs, and fever in two pregnant women abated rapidly with azithromycin. Prospective human trials are needed.

引用

页码：2817 / 2818

页数：2

共 17 条

[1] Successful double-blinded, randomized, placebo-controlled field trial of azithromycin and doxycycline as prophylaxis for malaria in western Kenya [J].