Convenient synthesis of fragment E of antibiotic, nosiheptide

被引：24

作者：

Shin, CG ^{[1
]}

Yamada, Y ^{[1
]}

Hayashi, K ^{[1
]}

Yonezawa, Y ^{[1
]}

Umemura, K ^{[1
]}

Tanji, T ^{[1
]}

Yoshimura, J ^{[1
]}

机构：

[1] IWAKI MEISEI UNIV,COLL SCI & ENGN,IWAKI,FUKUSHIMA 970,JAPAN

来源：

HETEROCYCLES | 1996年 / 43卷 / 04期

关键词：

D O I：

10.3987/COM-96-7396

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A convenient synthesis of Fragment E, 4-hydroxymethyl-3-methylindole-2-carboxylic acid (1), from 2-methyl-3-nitrobenzyl alcohol through six steps conversion in 32% overall yield is described.

引用

页码：891 / 898

页数：8

共 10 条

[1] [Anonymous], 1973, ORG SYNTH COLL
[2] DEPIRE H, 1977, TETRAHEDRON, P1401
[3] DEPIRE H, 1977, TETRAHEDRON, P1397
[4] HOSHINO T, 1932, LIEBIGS ANN CHEM, V35, P500
[5] KOERBERPLE K, 1994, SYNLETT, P759
[6] HIGHLY MODIFIED CYSTEINE-CONTAINING ANTIBIOTICS - CHEMICAL-STRUCTURE AND CONFIGURATION OF NOSIHEPTIDE
PASCARD, C
DUCRUIX, A
LUNEL, J
PRANGE, T
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1977, 99 (19) : 6418 - 6423
[7] STRUCTURE OF NOSIHEPTIDE, A POLYTHIAZOLE-CONTAINING ANTIBIOTIC
PRANGE, T
DUCRUIX, A
PASCARD, C
LUNEL, J
[J]. NATURE, 1977, 265 (5590) : 189 - 190
[8] RHONEPOULENC SA, 1961, Patent No. 1392453
[9] SYNTHESES OF 2-[(1S,3S)-1-AMINO-3-CARBOXY-3-HYDROXYPROPYL]-THIAZOLE-4-CARBOXYLIC ACID AND THE TRIPEPTIDE SKELETON OF NOSIHEPTIDE CONTAINING THE ACID
SHIN, CG
NAKAMURA, Y
YAMADA, Y
YONEZAWA, Y
UMEMURA, K
YOSHIMURA, J
[J]. BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 1995, 68 (11) : 3151 - 3160
[10] UMEMURA K, 1995, SYNTHESIS-STUTTGART, P1423

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