Expression of neurotrophin-3 mRNA in the rat visual cortex and hippocampus is influenced by environmental conditions

被引：58

作者：

Torasdotter, M ^{[1
]}

Metsis, M ^{[1
]}

Henriksson, BG ^{[1
]}

Winblad, B ^{[1
]}

Mohammed, AH ^{[1
]}

机构：

[1] KAROLINSKA INST,DEPT MED CHEM,MOL NEUROBIOL LAB,S-17177 STOCKHOLM,SWEDEN

来源：

NEUROSCIENCE LETTERS | 1996年 / 218卷 / 02期

关键词：

neurotrophin-3; visual cortex; hippocampus; environmental complexity; plasticity; learning; in situ hybridization;

D O I：

10.1016/S0304-3940(96)13127-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Environmental enrichment results in structural changes in the brain. Recent findings indicate involvement of neurotrophins in neuronal plasticity. This study examined the effect of environmental complexity on the levels of neurotrophin-3 (NT-3) mRNA in the rat visual cortex and hippocampus, studied by in situ hybridization. Rats housed in groups in a complex, stimulating environment had significantly higher levels of NT-3 mRNA in the visual cortex and the hippocampus than rats housed in individual cages without stimulating objects. These results indicate a possible role for NT-3 in synaptic plasticity.

引用

页码：107 / 110

页数：4

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