Tandem retro-aldol/Wittig/Michael and related cascade processes

被引：10

作者：

Beltran-Rodil, Sandra ^{[1
]}

Donald, James R. ^{[1
]}

Edwards, Michael G. ^{[1
]}

Raw, Steven A. ^{[2
]}

Taylor, Richard J. K. ^{[1
]}

机构：

[1] Univ York, Dept Chem, York YO10 5DD, N Yorkshire, England

[2] AstraZeneca, Proc Res & Dev, Macclesfield SK10 2NA, Cheshire, England

来源：

TETRAHEDRON LETTERS | 2009年 / 50卷 / 26期

关键词：

OXIDATION PROCESSES; SEQUENCES;

D O I：

10.1016/j.tetlet.2009.02.115

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A number of novel tandem sequences initiated by a retro-aldol process are described along with preliminary scope and limitation studies. These include (i) retro-aldol/Wittig trapping/intramolecular Michael addition, (ii) retro-aldol/aza-Wittig/intramolecular imine addition, (iii) retro-aldol/Henry/intramolecular Michael addition and (iv) retro-aldol/Knoevenagel/intramolecular Michael addition sequences. A range of novel functionalised cyclopentanes, and related systems, are described which should prove to be useful synthetic building blocks. (C) 2009 Elsevier Ltd. All Fights reserved.

引用

页码：3378 / 3380

页数：3

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