A global genomic transcriptional code associated with CNS-expressed genes

被引：40

作者：

Bailey, Peter J.

Klos, Joanna M.

Andersson, Elisabet

Karlen, Mattias

Kallstrom, Magdalena

Ponjavic, Jasmina

Muhr, Jonas

Lenhard, Boris

Sandelin, Albin

Ericson, Johan ^{[1
]}

机构：

[1] Karolinska Inst, Med Nobel Inst, Dept Cell & Mol Biol, S-17177 Stockholm, Sweden

[2] Karolinska Inst, Med Nobel Inst, Ludwig Inst Canc Res, S-17177 Stockholm, Sweden

[3] Univ Oxford, Dept Physiol Anat & Genet, MRC Funct Genet Unit, Oxford OX1 3QX, England

[4] RIKEN Yokohama Inst, RIKEN Genom Sci Ctr, Genom Network Project Core Grp, Yokohama, Kanagawa 2300045, Japan

[5] Univ Bergen, Computat Biol Unit, Bergen Ctr Computat Sci, N-5008 Bergen, Norway

来源：

EXPERIMENTAL CELL RESEARCH | 2006年 / 312卷 / 16期

基金：

英国医学研究理事会;

关键词：

HCNR; CNS; development; transcriptional code; Sox; POU; homeodomain; transcription factor;

D O I：

10.1016/j.yexcr.2006.06.017

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Highly conserved non-coding DNA regions (HCNR) occur frequently in vertebrate genomes, but their functional roles remain unclear. Here, we provide evidence that a large portion of HCNRs are enriched for binding sites for Sox, POU and Homeodomain transcription factors, and such HCNRs can act as cis-regulatory regions active in neural stem cells. Strikingly, these HCNRs are linked to several hundreds of genes expressed in the developing CNS and they may exert locus-wide regulatory effects on multiple genes flanking their genomic location. Moreover, these data imply a unifying transcriptional logic for a large set of CNS-expressed genes in which Sox and POU proteins act as generic promoters of transcription while Homeodomain proteins control the spatial expression of genes through active repression. (c) 2006 Elsevier Inc. All rights reserved.

引用

页码：3108 / 3119

页数：12

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