The broken mouse: the role of development, plasticity and environment in the interpretation of phenotypic changes in knockout mice

被引：95

作者：

Gingrich, JA ^{[1
]}

Hen, R

机构：

[1] Columbia Univ, Dept Psychiat, Div Dev Psychobiol, New York, NY 10032 USA

[2] Columbia Univ, Ctr Neurobiol & Behav, New York, NY 10032 USA

来源：

CURRENT OPINION IN NEUROBIOLOGY | 2000年 / 10卷 / 01期

关键词：

D O I：

10.1016/S0959-4388(99)00061-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

With the advent of gene knockout technology has arisen the problem of how to interpret the resulting phenotypic changes in mice lacking specific genes. This problem is especially relevent when applied to behavioral phenotypes of knockout mice, which are difficult to interpret. Of particular interest are the roles of development and compensatory changes, as well as other factors, such as the influence of the gene knockout on nearby genes, the effect of the genetic background strain, maternal behavioral influences, and pleiotrophy.

引用

页码：146 / 152

页数：7

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