Bone turnover markers in the management of postmenopausal osteoporosis

被引：161

作者：

Brown, Jacques P. ^{[1
]}

Albert, Caroline ^{[2
]}

Nassar, Bassam A. ^{[3
]}

Adachi, Jonathan D. ^{[4
]}

Cole, David ^{[5
]}

Davison, K. Shawn ^{[1
]}

Dooley, Kent C. ^{[6
]}

Don-Wauchope, Andrew ^{[4
]}

Douville, Pierre ^{[1
]}

Hanley, David A. ^{[7
]}

Jamal, Sophie A. ^{[5
]}

Josse, Robert ^{[5
]}

Kaiser, Stephanie ^{[3
]}

Krahn, John ^{[8
]}

Krause, Richard ^{[7
,9
]}

Kremer, Richard ^{[10
]}

Lepage, Raymond ^{[11
]}

Letendre, Elaine ^{[2
]}

Morin, Suzanne ^{[10
]}

Ooi, Daylily S. ^{[12
]}

Papaioaonnou, Alexandra ^{[4
]}

Ste-Marie, Louis-Georges ^{[2
]}

机构：

[1] Univ Laval, Quebec City, PQ, Canada

[2] Univ Montreal, Montreal, PQ, Canada

[3] Dalhousie Univ, Halifax, NS, Canada

[4] McMaster Univ, Hamilton, ON, Canada

[5] Univ Toronto, Toronto, ON, Canada

[6] LifeLabs Victoria Reg Lab, Victoria, BC, Canada

[7] Univ Calgary, Calgary, AB, Canada

[8] Univ Saskatchewan, Saskatoon, SK, Canada

[9] Calgary Lab Serv, Calgary, AB, Canada

[10] McGill Univ, Montreal, PQ, Canada

[11] Lab Med Biron, Brossard, PQ, Canada

[12] Univ Ottawa, Ottawa, ON, Canada

来源：

CLINICAL BIOCHEMISTRY | 2009年 / 42卷 / 10-11期

关键词：

Biochemical markers; Bone turnover; Osteoporosis; Monitoring; Fracture; Biological variability; Recommendations; VERTEBRAL FRACTURE RISK; HEALTHY PREMENOPAUSAL WOMEN; COLLAGEN C-TELOPEPTIDES; LINKED N-TELOPEPTIDES; AUTOMATED SERUM ASSAY; BIOCHEMICAL MARKERS; I COLLAGEN; MINERAL DENSITY; BIOLOGICAL VARIABILITY; DEGRADATION-PRODUCTS;

D O I：

10.1016/j.clinbiochem.2009.04.001

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

100118 [医学信息学]; 100208 [临床检验诊断学];

摘要：

Osteoporosis is the most common cause of fragility fractures. Bone remodelling is essential for repairing damaged areas within bone to preserve bone strength and for assisting in mineral homeostases. In young adults, bone remodelling is Usually balanced with approximately as much bone replaced as is removed during each remodelling cycle. However, when remodelling becomes accelerated in combination with an imbalance that favours bone resorption over formation, such as during menopause, precipitous losses in bone mass occur. Bone turnover markers (BTMs) measure the rate of bone remodelling allowing for a dynamic assessment of skeletal status and hold promise in identifying those at highest risk of rapid bone loss and subsequent fracture. Further, the use of BTMs to monitor individuals administered osteoporosis therapy is attractive as monitoring anti-fracture efficacy with bone mineral density has significant limitations. This review details remodelling biology, pre-analytical and analytical sources of variability for BTMs, describes the most commonly used resorption and formation markers, and offers some guidelines for their use and interpretation in the laboratory and the clinic. (c) 2009 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

引用

页码：929 / 942

页数：14

共 136 条

[1]

Determinants of bone turnover markers in healthy premenopausal women [J].