Co-immobilization of an Enzyme and a Metal into the Compartments of Mesoporous Silica for Cooperative Tandem Catalysis: An Artificial Metalloenzyme

被引：193

作者：

Engstrom, Karin ^{[1
]}

Johnston, Eric V. ^{[1
]}

Verho, Oscar ^{[1
]}

Gustafson, Karl P. J. ^{[1
]}

Shakeri, Mozaffar ^{[1
]}

Tai, Cheuk-Wai ^{[2
,3
]}

Backvall, Jan-E. ^{[1
]}

机构：

[1] Stockholm Univ, Arrhenius Lab, Dept Organ Chem, S-10691 Stockholm, Sweden

[2] Stockholm Univ, Dept Mat & Environm Chem, S-10691 Stockholm, Sweden

[3] Stockholm Univ, Berzeli Ctr EXSELENT Porous Mat, Arrhenius Lab, S-10691 Stockholm, Sweden

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 52期

基金：

瑞典研究理事会;

关键词：

artificial deracemase; biocatalysis; dynamic kinetic resolution; hybrid catalysts; metal catalysis; DYNAMIC KINETIC RESOLUTION; MESOCELLULAR FOAM; PALLADIUM NANOPARTICLES; PHOTOSYSTEM-II; PROTEIN; HYDROGENATION; RACEMIZATION; NITROGENASE; CONVERSION; LIPASE;

D O I：

10.1002/anie.201306487

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Surpassing nature: A hybrid catalyst in which Candida antarctica lipase B and a nanopalladium species are co-immobilized into the compartments of mesoporous silica is presented. The metal nanoparticles and the enzyme are in close proximity to one another in the cavities of the support. The catalyst mimics a metalloenzyme and was used for dynamic kinetic resolution of a primary amine in high yield and excellent enantioselectivity. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：14006 / 14010

页数：5

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