Family-based association studies of α-adrenergic receptor genes in chromosomal regions with linkage to bipolar affective disorder

被引：6

作者：

Abou Jamra, R

Schumacher, J

Golla, A

Richter, C

Otte, ACJ

Schulze, TG

Ohlraun, S

Maier, W

Rietschel, M

Cichon, S

Propping, P

Nöthen, MM

机构：

[1] Univ Bonn, Inst Human Genet, D-53111 Bonn, Germany

[2] Univ Bonn, Inst Med Biometry Informat & Epidemiol, D-5300 Bonn, Germany

[3] Cent Inst Mental Hlth, D-6800 Mannheim, Germany

[4] Univ Bonn, Dept Psychiat, D-5300 Bonn, Germany

[5] Univ Antwerp, Dept Med Genet, B-2020 Antwerp, Belgium

来源：

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS | 2004年 / 126B卷 / 01期

关键词：

manic-depression; transmission disequilibrium test; adrenergic receptor genes;

D O I：

10.1002/ajmg.b.20145

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Several lines of evidence suggest an involvement of the noradrenergic neurotransmitter system in the pathogenesis of bipolar affective disorder (BPAD). Three genes for alpha-adrenergic receptors (ADRA) are located in chromosomal regions that showed evidence for linkage: The alpha(1c)-adrenergic (ADRA-1C) receptor gene on 8p21, the alpha(2a)-adrenergic (ADRA-2A) receptor gene on 10q25, and the alpha(2c)-adrenergic (ADRA-2C) receptor on 4p16. In a BPAD sample of 120 parent-offspring triads, we genotyped a 492 Cys/Arg variant in exon 2 of the ADRA-1C gene, a -1291 G/C variant in the 5' UTR of the ADRA-2A gene, and a STR marker (adra2c1) in the 5' UTR of the ADRA-2C gene. Using the Transmission Disequilibrium Test (TDT), no significant differences in transmissions were observed for any of the three ADRA genes. (C) 2003 Wiley-Liss, Inc.

引用

页码：79 / 81

页数：3

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