Estrogen regulation of immune responses after injury

被引:77
作者
Kovacs, EJ [1 ]
Messingham, KAN
Gregory, MS
机构
[1] Loyola Univ Chicago, Immunol & Aging Program, Maywood, IL 60153 USA
[2] Loyola Univ Chicago, Alcohol Res Program, Maywood, IL USA
[3] Loyola Univ Chicago, Burn & Shock Trauma Inst, Maywood, IL USA
[4] Loyola Univ Chicago, Stritch Sch Med, Dept Cell Biol Neurobiol & Anat, Maywood, IL 60153 USA
[5] Loyola Univ Chicago, Dept Surg, Maywood, IL USA
关键词
macrophage; gender; cytokines; trauma; interleukin-6; gonadal steroids hormones;
D O I
10.1016/S0303-7207(02)00106-5
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
There is a naturally occurring gender difference in immune responses which persists after traumatic injury. Physiological levels of 17beta-estradiol (E-2) are immunostimulatory, whereas high pregnancy and superphysiological levels are immunosuppressive. In contrast, at all concentrations, testosterone suppresses immune responses. Evidence from this laboratory and others suggest that the gender difference in immune responses after injury is mediated in part by alterations in the circulating levels of gonadal steroid hormones through modulation of production of inflammatory. and immunoregulatory cytokines, including interleukin-6 (IL-6). Aberrant production of IL-6 is known to be an important mediator of immunity after injury. Since E-2 is a critical regulator of IL-6 production and overall immune function, it suggests gender specific therapies should be considered for the treatment of patients. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码:129 / 135
页数:7
相关论文
共 103 条
[1]  
AHMED SA, 1985, AM J PATHOL, V121, P531
[2]  
ALEXANDER JW, 1966, ARCH SURG-CHICAGO, V93, P75
[3]  
ALEXANDER JW, 1990, J TRAUMA, V30, pS70
[4]   Testosterone: the culprit for producing splenocyte immune depression after trauma hemorrhage [J].
Angele, MK ;
Ayala, A ;
Cioffi, WG ;
Bland, KI ;
Chaudry, IH .
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 1998, 274 (06) :C1530-C1536
[5]   Effect of gender and sex hormones on immune responses following shock [J].
Angele, MK ;
Schwacha, MG ;
Ayala, A ;
Chaudry, IH .
SHOCK, 2000, 14 (02) :81-90
[6]  
Angele MK, 1997, ARCH SURG-CHICAGO, V132, P1207
[7]  
AYALA A, 1993, ARCH SURG-CHICAGO, V128, P89
[8]   INTERLEUKIN-6 PRODUCTION AFTER THERMAL-INJURY - EVIDENCE FOR NONMACROPHAGE SOURCES IN THE LUNG AND LIVER [J].
BANKEY, PE ;
WILLIAMS, JG ;
GUICE, KS ;
TAYLOR, SN .
SURGERY, 1995, 118 (02) :431-439
[9]   Interleukin-6 in the injured patient marker of injury or mediator of inflammation? [J].
Biffl, WL ;
Moore, EE ;
Moore, FA ;
Peterson, VM .
ANNALS OF SURGERY, 1996, 224 (05) :647-664
[10]   PROLACTIN, CORTICOTROPIN, AND GONADOTROPIN CONCENTRATIONS FOLLOWING THERMAL-INJURY IN ADULTS [J].
BRIZIOMOLTENI, L ;
MOLTENI, A ;
WARPEHA, RL ;
ANGELATS, J ;
LEWIS, N ;
FORS, EM .
JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE, 1984, 24 (01) :1-7